5 month old Bullmastiff won't toilet train..help please?

We got our bullmastiff at 8weeks old, she is now 21weeks old. She was bottle fed as her mother did not have enough milk. She is only interested in food, completely disinterested in play, skittish on walks I give her treats leash training her so its nice for her and then she pees and poos in her crate and anywhere she pleases. I am here all day everyday with kids so she is let out hourly, sometimes she walks back in from the garden and within 5minutes has messed the floor or her crate. I praise her when she goes outside, I make a big deal telling her how good she is, I don't go crazy when she messes inside either, a quick sharp 'No' and then out the door. She is brought out to pee at midnight before I go to bed and then when I get up at 7 am she has peed and pooed in her crate and walked and lay in it and doesn't seem to care at all. I am losing my mind, this is my second bullmastiff and I have had dogs all my life and never experienced this. Please help I am losing my mind
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